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Call your doctor for medical advice about side effects. 42 FDA Approves First Generic Versions of Aciphex to treat GERD fda approves first generic versions of aciphex article The U. ® Community/Ambulatory Care Edition through February 28, 2019.. Aciphex reduces the amount of acid in your stomach It's the same medicine--omeprazole is the generic. If Aciphex works and doesn't cause side effects, that might be a solution unless something else is going on. The most common side effect possibly related to ACIPHEX® is headache. I've taken Eisai's brand Aciphex for 15years with great success. Aciphex (rabeprazole) is a member of the proton pump inhibitors drug class and is commonly used for Barrett's Esophagus, Duodenal Ulcer, Duodenal Ulcer Prophylaxis, and others. Aciphex Generic name: rabeprazole sodium Reviewed by N France, BPharm on February 10, 2020 Uses Important Before taking How to take Side effects Images General information Storage Ingredients What is Aciphex? 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