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Active antihistamine ingredients in nasal sprays are azelastine or olopatadine. Previously available only by prescription, the FDA has now granted azelastine nonprescription status. This nasal spray can be used in combination with other over-the-counter anti-histamines medications taken orally like zyrtec, claritin, allegra, and benadryl. But when you're looking for an over-the-counter (OTC) medication, you'll need to know what the possible interactions are These sprays are available over the counter or by prescription. 39 FDA approves antihistamine nasal spray for over-the-counter use Download PDF Copy Reviewed by Emily Henderson, B. Let’s take a look at different types of nasal sprays so you can figure out which one might work best for treating your hay fever symptoms Up to 24 hour relief of: Nasal congestion. 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T see post-nasal drip) and progressively put me on the following medications over the past eight months or so when I failed to improve: 1. The most common decongestant nasal sprays are oxymetazoline⁴ (Afrin, Sinex, Dristan) and phenylephrine⁵ (Neo-Synephrine). Designed to help relieve a stuffy nose so you can breathe easier, decongestant sprays work by shrinking blood vessels in the nasal passage. In Each Spray Other Information: Store between 20 degrees to 25 degrees C (68 degrees to 77 degrees F) These sprays are available over the counter or by prescription. The US Department of Justice has announced that Akorn will pay . This medication is an antihistamine, which means it works by limiting the activity of the body's histamines The US Department of Justice has announced that Akorn will pay . 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